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Target intelligence / Profile preview
Glutathione Transferase (GST)
- Target
- GST
- Molecular classification
- Enzyme, Transferase
01
Overview
Glutathione transferases (GSTs) are a family of enzymes that catalyze the conjugation of glutathione to a wide variety of electrophilic compounds, facilitating their detoxification and excretion. They play a central role in phase II metabolism and have peroxidase and isomerase functions, regulate stress-induced signaling pathways and bind non-catalytically to various ligands. Overexpression of certain GST isoforms is linked with cancer development and chemotherapeutic resistance.
- Other names
- Glutathione S-transferaseGSTs
02
Mechanism of action
Catalyzes the conjugation of glutathione (GSH) to electrophilic compounds, facilitating their detoxification and excretion.
03
Biological functions
DetoxificationRedox homeostasisPeroxidase activityIsomerase activityLigand bindingRegulation of cell proliferationRegulation of apoptosis
04
Disease associations
CancerOxidative stress-related diseasesCOVID-19
05
Safety considerations
Overexpression can lead to drug resistance in cancer.Genetic polymorphisms can influence susceptibility to diseases.
06
Biomarkers
GST expression levels in tumorsGenetic polymorphisms in GST genes
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