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Target intelligence / Profile preview
Gluten-specific T Cell Receptor
- Molecular classification
- Receptor, T Cell Receptor (TCR)
01
Overview
Gluten-specific T cell receptors (TCRs) are specialized receptors expressed on the surface of T cells that recognize gluten-derived peptides presented by HLA class II molecules, particularly HLA-DQ2.5 and HLA-DQ8. These TCRs play a central role in the pathogenesis of celiac disease, an autoimmune disorder triggered by dietary gluten. The unique sequence features, especially TRAV26–1/TRBV7–2 pairing with the R-motif, make these receptors promising biomarkers and potential therapeutic targets.
02
Mechanism of action
Engineered antibodies mimicking TCRs can block pathogenic T cell activation.
03
Biological functions
Antigen recognitionT cell activationImmune responseB cell helpCytokine production
04
Disease associations
Celiac disease
05
Safety considerations
Potential for broad immunosuppression if targeting is not specific enoughRisk of off-target effects
06
Biomarkers
TRAV26-1/TRBV7-2 pairingR-motif in CDR3β
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