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Glyceraldehyde-3-phosphate (G3P (also GA3P, GADP, GAP, TP, GALP, PGAL))
- Target
- G3P (also GA3P, GADP, GAP, TP, GALP, PGAL)
- Molecular classification
- Small molecule metabolite, Aldotriose, Carbohydrate, Phosphate ester
01
Overview
Glyceraldehyde-3-phosphate is a three-carbon phosphorylated sugar (aldotriose) that serves as an important metabolic intermediate in glycolysis, gluconeogenesis, the Calvin cycle in photosynthesis, tryptophan biosynthesis, and thiamine metabolism. It is formed from the cleavage of fructose 1,6-bisphosphate and can interconvert with dihydroxyacetone phosphate. It is not itself a protein, enzyme, receptor, or other classic drug target, but rather a substrate or product in central metabolic pathways in all domains of life. The correct drug target associated with this molecule is glyceraldehyde-3-phosphate dehydrogenase (GAPDH), an enzyme that acts on G3P.
- Other names
- triose phosphate3-phosphoglyceraldehydeGA3PGADPGAPTPGALPPGAL
02
Biological functions
Intermediate in glycolysisIntermediate in gluconeogenesisIntermediate in photosynthesisIntermediate in tryptophan biosynthesisIntermediate in thiamine biosynthesis
03
Biomarkers
Potential food biomarker (as it can be detected in foods like berries and quinoa)
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