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Target intelligence / Profile preview
Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH)
- Target
- GAPDH
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a highly conserved, multifunctional enzyme best known for its central role in glycolysis. It catalyzes the sixth step of glycolysis, converting glyceraldehyde-3-phosphate (G3P) into 1,3-bisphosphoglycerate with the concomitant reduction of NAD+ to NADH. While GAPDH’s primary function is in glycolysis, it also has several non-glycolytic roles, including regulation of cell death and survival pathways, participation in nuclear functions such as DNA repair, and interaction with other proteins affecting cellular fate under stress conditions. Altered expression or activity of GAPDH has been implicated in various diseases, including cancer, neurodegenerative diseases, and diabetes.
02
Mechanism of action
Inhibition of enzymatic activity
03
Biological functions
GlycolysisRegulation of cell death and survivalDNA repairCell signalingApoptosis regulationEnergy metabolism
04
Disease associations
CancerNeurodegenerative diseaseDiabetes
05
Safety considerations
Potential effects on normal cells due to multiple functionsOff-target effects on glycolysis
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