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Glyceraldehyde-3-phosphate dehydrogenase pseudogene 14 (GAPDHP14)

Target: GAPDHP14
Molecular classification: Other (Pseudogene)

Overview

Glyceraldehyde-3-phosphate dehydrogenase pseudogene 14 (GAPDHP14) is a processed pseudogene derived from the GAPDH gene, a widely expressed enzyme in glycolysis. Pseudogenes like GAPDHP14 are genomic sequences with high similarity to functional genes but are typically nonfunctional due to mutations, lack of regulatory elements, or frameshifts[1][2][4]. GAPDH pseudogenes are particularly numerous in the human genome, likely reflecting the high expression and multifunctionality of the parental GAPDH gene[1][3]. Though most pseudogenes do not transcribe functional proteins and have no direct biological or disease role, some may influence gene expression or participate in genome evolution or homologous recombination events. However, there1s currently no evidence to suggest that GAPDHP14 has any such function or is a drug target[1][4][5].

Other names: GAPDP14GC21U900186GC21P029516GC21P030595GC21P016004

Biological functions

Other (By itself, none; processed pseudogenes generally lack biological function, but pseudogenes in general may have rare regulatory effects)

Disease associations

Other (No direct disease association; in rare cases, pseudogenes may participate indirectly in disease through sequence homology-mediated effects or as regulators, but no evidence is available for GAPDHP14 specifically)

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