Glyceraldehyde-3-phosphate dehydrogenase pseudogene 15 (GAPDHP15)

Glyceraldehyde-3-phosphate dehydrogenase pseudogene 15 (GAPDHP15) is one of dozens of GAPDH-related pseudogenes present in the human genome[2][4][6]. Pseudogenes are DNA sequences that resemble known genes but do not encode functional proteins; processed pseudogenes like GAPDHP15 typically originate from the retrotransposition of mature mRNA from the parental gene (in this case, GAPDH)[2][8]. Unlike the functional enzyme GAPDH, which is crucial for glycolysis and diverse cellular functions[1][3], GAPDHP15 does not produce an active protein and is not considered a receptor, enzyme, or direct target for therapeutic drugs[4][6]. GAPDH pseudogenes are present in high copy number in both primate and rodent genomes[2], but their biological role is thought to be limited to potential regulatory influences or as markers in genomic studies, rather than direct involvement in diseases or drug interactions. No established interacting drugs, mechanisms of action, biomarker uses, or safety concerns are associated with GAPDHP15. It is not considered a misspelling or erroneous entry; the name matches current genomic annotations (HGNC:13950, NCBI Gene: 642317, Ensembl: ENSG00000214563)[4][6]. If a canonical protein target (e.g., GAPDH) is sought instead, this would refer to "Glyceraldehyde-3-phosphate dehydrogenase," a functional, widely expressed enzyme with significant metabolic and regulatory roles[1][3].

Other names

GAPDH-LpGAPDP15b55C20.4GAPDHP15