Glyceraldehyde-3-phosphate dehydrogenase pseudogene 28 (GAPDHP28)

Glyceraldehyde-3-phosphate dehydrogenase pseudogene 28 (GAPDHP28) is a member of the large family of pseudogenes related to the enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a key glycolytic enzyme[1][3][7]. Pseudogenes, such as GAPDHP28, are genomic DNA sequences similar to normal genes but typically carry mutations or rearrangements that prevent their translation into functional proteins[3][5]. Although pseudogenes are usually noncoding and biologically inactive, research increasingly indicates that some can contribute to gene regulation, for instance, by serving as microRNA sponges or through their transcripts[5][8]. There is no evidence that GAPDHP28 protein is produced; thus, it cannot serve as a classical therapeutic target. Key points: - GAPDHP28 refers specifically to a pseudogene and not to the functional GAPDH enzyme. - Pseudogenes related to GAPDH are extremely abundant in the mammalian genome, with more than 200 copies in rodents and dozens in humans, reflecting evolutionary gene duplication events[3][7]. - GAPDHP28 itself is not directly involved in any known physiological process, nor is it an actionable therapeutic target by current scientific standards[1][3][6]. If you require structured information about the functional glyceraldehyde-3-phosphate dehydrogenase enzyme (GAPDH), that would be a distinct target, unrelated to pseudogenes such as GAPDHP28.

Other names

GAPDHP28