Glyceraldehyde-3-phosphate dehydrogenase pseudogene 50 (GAPDHP50)

Glyceraldehyde-3-phosphate dehydrogenase pseudogene 50 (GAPDHP50) is **not a protein-coding gene** but rather a **pseudogene**, meaning it is a genomic locus with sequence similarity to the functional glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene but rendered **non-functional** due to disabling mutations such as frameshifts or premature stop codons[1][3][4][6][9]. Pseudogenes like GAPDHP50 are typically considered genetic relics and do not produce functional protein, although some pseudogenes may be transcribed or exert regulatory effects at the RNA level[1][5][7]. \nGAPDH itself is a key glycolytic enzyme, but human and other vertebrate genomes contain **dozens or even hundreds of GAPDH pseudogenes**; the number of these pseudogenes varies by species and many are processed (retrotransposed) copies[2][9]. \nThere is **no evidence** that GAPDHP50, specifically, plays a recognized biological function, has drug interactions, is used as a biomarker, or is considered a therapeutic target. Its nomenclature can easily be confused with the functional GAPDH gene or with other pseudogenes, a common pitfall in experimental design and interpretation[9]. \nThe existence of many highly similar pseudogenes can complicate molecular assays such as qPCR and genotyping when GAPDH is used as a reference gene[9]. \nIn summary, GAPDHP50 is a **non-coding pseudogene with no known therapeutic, diagnostic, or mechanistic drug relevance**, and is not a valid molecular target.

Other names

GAPDHP50Glyceraldehyde 3 Phosphate Dehydrogenase Pseudogene 50