Glyceraldehyde-3-phosphate dehydrogenase pseudogene 60 (GAPDHP60)

Glyceraldehyde-3-phosphate dehydrogenase pseudogene 60 is a processed human pseudogene derived from the parent GAPDH gene via retrotransposition. It does not encode a functional protein and does not participate directly in glycolysis or other biological processes attributed to GAPDH. Its presence in the genome is a consequence of historical gene duplication and retrotransposition events[1][2]. Unlike the functional GAPDH gene, which is central to glycolysis and many cellular processes, GAPDHP60 lacks coding capacity and is not implicated in disease or therapeutic mechanisms. Pseudogenes like GAPDHP60 may serve as genomic markers of evolutionary history, but so far, no data indicate a direct role in disease or drug response. If a query intends to refer to GAPDH, the functional metabolic enzyme and known research target, the correct target should be "Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)"[2]. Note: GAPDHP60 is frequently misinterpreted as a drug target due to confusion with functional enzymes or regulatory noncoding RNAs; it is solely a genomic pseudogene without coding or regulatory function currently attributed[2].

Other names

GAPDHL4GAPDL4

None. There is no mechanism of action described for drugs against this pseudogene.