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Target intelligence / Profile preview
Glyceraldehyde-3-phosphate dehydrogenase pseudogene 64 (GAPDHP64)
- Target
- GAPDHP64
- Molecular classification
- Pseudogene, Processed pseudogene
01
Overview
Glyceraldehyde-3-phosphate dehydrogenase pseudogene 64 (GAPDHP64) is classified as a pseudogene—a DNA sequence resembling the functional GAPDH gene but rendered nonfunctional due to disabling mutations. Pseudogenes do not encode functional proteins and are generally considered biologically inactive, though some may be transcribed to non-coding RNAs with potential minor regulatory functions. GAPDHP64 itself has no reported functional protein product, disease association, druggability, or role as a pharmacologic biomolecule. Annotation resources confirm that it is not a therapeutic target but rather a genomic artifact resulting from gene duplication or retrotransposition events that have lost protein-coding capability.
02
Mechanism of action
None applicable, as pseudogenes do not encode a protein product to be targeted by drugs.
03
Biological functions
None established as a functional protein. Pseudogenes are nonfunctional remnants of genes; however, some pseudogenes may be transcribed as RNA, occasionally acting in regulatory (non-coding RNA) roles.
04
Disease associations
None directly for GAPDHP64. Most pseudogenes do not have direct disease roles, though in rare cases, expression or regulation of pseudogenes may be linked to diseases through regulatory RNA mechanisms.
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