Glyceraldehyde-3-phosphate dehydrogenase pseudogene 67 (GAPDHP67)

Glyceraldehyde-3-phosphate dehydrogenase pseudogene 67 (GAPDHP67) is one of many pseudogenes derived from the GAPDH gene. Pseudogenes are nonfunctional segments of DNA similar to functional genes but typically lack protein-coding capacity due to disabling mutations, truncations, or regulatory sequence loss. GAPDH has an unusually large number of pseudogenes in the human genome, most arising from retrotransposition, but these pseudogenes—including GAPDHP67—do not encode the active glycolytic enzyme and are not biological targets for drugs or therapeutic intervention[4].\n\nKey clarification:\nGAPDH itself is a functionally critical enzyme in glycolysis with many reported moonlighting roles in cell biology, disease, and drug response[1][2][3]. However, pseudogenes like GAPDHP67 are inactive genomic copies and not targets in drug discovery, diagnosis, or therapy[4]. No evidence supports their protein expression, functional activity, or role as a drug target.\n\nIf you need information on the active enzyme GAPDH, please specify—the current query targets a non-coding pseudogene.

Other names

Glyceraldehyde-3-phosphate dehydrogenase pseudogene 67GAPDH pseudogene 67