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Target intelligence / Profile preview
Glyceraldehyde-3-phosphate dehydrogenase pseudogene 74 (GAPDHP74)
- Target
- GAPDHP74
- Molecular classification
- Other (Pseudogene)
01
Overview
Glyceraldehyde-3-phosphate dehydrogenase pseudogene 74 (GAPDHP74) is a processed pseudogene, meaning it originated from retrotransposition of mRNA from its parent gene, GAPDH, but does not encode a functional enzyme or receptor[1]. GAPDH itself is a highly conserved glycolytic enzyme with numerous cellular functions, but its pseudogenes, including GAPDHP74, are nonfunctional genomic copies found in multiple species[1]. The high number of GAPDH pseudogenes in the human genome reflects the retrotranspositional activity of the parent gene, but these pseudogenes, including GAPDHP74, do not have recognized coding or regulatory roles, nor are they considered therapeutic or diagnostic targets[1].
- Other names
- GAPDHP74
02
Mechanism of action
None
03
Biological functions
None (Pseudogenes do not have protein-coding functions; GAPDHP74 does not encode a functional protein)
04
Disease associations
None (No established role in disease; parent gene GAPDH’s pseudogenes have not been shown to directly contribute to disease processes)
05
Safety considerations
None
06
Biomarkers
None (not used as a biomarker)
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