Glycerate kinase (GLYCTK)

Glycerate kinase (GLYCTK) is a cytoplasmic and mitochondrial enzyme that facilitates the phosphorylation of (R)-glycerate to 3-phosphoglycerate, a crucial step in several cellular metabolic processes including amino acid and lipid metabolism. Mutations disrupting GLYCTK’s activity cause D-glyceric aciduria, a rare autosomal recessive disorder marked by neurological deficits and developmental delay due to accumulation of D-glyceric acid. The enzyme is essential for proper energy metabolism, with clinical importance in genetic diagnostics rather than as a drug target.

Other names

GLYCTKHBEBP4LP5910HBEBP2HBeAg-binding protein 4HBeAg-binding protein 2HBeAgBP4AGlycerate-3-kinaseD-glycerate kinaseD-glyceric acid kinase

Not applicable (no known drugs targeting this enzyme); mutation causes loss of enzyme function