Target intelligence / Profile preview

Glycerol kinase (GK)

Target: GK
Molecular classification: Enzyme, Kinase

Overview

Glycerol kinase (GK) converts glycerol to glycerol 3-phosphate, the first committed step in de novo glycerolipid synthesis. It is primarily expressed in the liver and kidney and plays a crucial role in glycerolipid metabolism. In the triglyceride synthesis pathway, it provides the glycerol-3-phosphate backbone that is acylated to form triacylglycerols.

Mechanism of action

N/A

Biological functions

PhosphorylationGlycerol metabolismTriglyceride synthesis

Disease associations

Metabolic disordersType 2 diabetes (potential)

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