Glycerophospholipid metabolism enzyme (null)

Glycerophospholipid metabolism enzymes are a diverse group of enzymes that catalyze the synthesis, remodeling, and degradation of glycerophospholipids—the major structural lipids of eukaryotic cellular membranes[6][1]. Key enzyme classes include acyltransferases (such as G3PAT, AGPAT), phospholipases (e.g., PLA2), kinases, and phosphatases[4][6]. These enzymes mediate multiple steps: the sequential acylation of glycerol-3-phosphate, head-group addition, remodeling of fatty acid chains, and breakdown of glycerophospholipids. The activity of these enzymes influences membrane composition, cellular signaling (for instance, by generating second messengers like DAG and IP3), and cellular functions such as growth, division, apoptosis, and responses to stress. Dysregulation of glycerophospholipid metabolism enzymes has been implicated in diseases such as cancer, cardiovascular disease, neurodegeneration, and inflammation, due to their role in cell proliferation, survival, and signaling[2][7]. Note: “Glycerophospholipid metabolism enzymes” is a functional category, not a unique molecular target—it includes many distinct enzymes, each encoded by separate genes and with potentially unique therapeutic relevance[4]. To obtain structured target data, further specificity (i.e., selecting a particular enzyme such as “Phospholipase A2” or “Lysophosphatidylcholine acyltransferase”) is necessary.

Other names

Glycerophospholipid metabolic enzymeGlycerophospholipid-metabolizing enzymeGlycerophospholipid metabolic pathway enzyme

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