Glyceryl Glucoside (GG)

Glyceryl glucoside is a natural carbohydrate derivative formed by the glycosylation of glycerol, functioning primarily as a potent osmoprotectant in extremophilic organisms such as cyanobacteria and certain resurrection plants [14]. In human dermatology, it is recognized as a sophisticated active ingredient that goes beyond simple hydration by actively modulating the skin's internal water-management system [1][7]. Its primary therapeutic mechanism involves the upregulation of Aquaporin-3 (AQP3), a critical trans-membrane protein that facilitates the movement of water and glycerol throughout the epidermis [3][4]. By increasing the density of these water channels, glyceryl glucoside significantly enhances skin barrier function, improves elasticity, and promotes keratinocyte vitality [3][10]. It is particularly effective for treating clinical conditions associated with chronic dryness, aging, or impaired barrier integrity, such as xerosis and inflammatory skin disorders [2][10]. Due to its high stability, safety, and ability to provide cellular-level hydration, it is widely utilized in therapeutic and premium cosmetic skincare formulations [8][12].

Other names

Gluco-glycerolalpha-D-glucosylglycerol2-O-alpha-D-glucopyranosyl-sn-glycerolGlucosylglycerolalpha-Glucosylglycerol

Upregulation of Aquaporin-3 (AQP3) gene expression and protein synthesis in keratinocytes, which facilitates the transport of water and glycerol across cell membranes [1][3][4]