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Target intelligence / Profile preview
Glycine Coagonist Site of N-methyl-D-aspartate Receptor (None)
- Target
- None
- Molecular classification
- Receptor, Ionotropic ligand-gated cation channel
01
Overview
The glycine coagonist site is a critical modulatory site on the NMDA receptor, an ionotropic glutamate receptor that plays a central role in excitatory neurotransmission, synaptic plasticity, and memory formation in the central nervous system. Activation of the NMDA receptor requires simultaneous binding of glutamate and glycine, making glycine an essential co-agonist for channel opening. Dysregulation or abnormal modulation at either agonist or coagonist sites has been implicated in various neurological disorders.
02
Mechanism of action
Antagonism of glycine coagonist binding to NMDA receptor GluN1 subunit
03
Biological functions
NeurotransmissionSynaptic plasticityLearningMemory formationNeurodevelopment
04
Disease associations
SchizophreniaEpilepsyNeurodegenerative diseaseCognitive dysfunction
05
Safety considerations
Potential for excitotoxicityNeurological side effects
06
Interacting drugs
L-701324
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