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Glycine-Gated NMDA Receptor

Molecular classification: Ionotropic glutamate receptor, Receptor, Ion channel, Ligand-gated ion channel

Overview

The glycine-gated NMDA receptor is a subtype of the N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor. Unlike canonical NMDA receptors, glycine-gated forms (GluN1/GluN3) are activated exclusively by glycine, mediating excitatory neurotransmission and calcium influx in the CNS. These receptors are implicated in neuronal development and responses to pathological conditions.

Mechanism of action

Ligand-gated ion channel activation

Biological functions

Excitatory neurotransmissionCalcium influxNeuronal excitabilitySynaptic plasticityLearningMemory formation

Disease associations

Neurological disordersIschemia-reperfusion injuryBlood-brain barrier dysfunction

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