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Target intelligence / Profile preview
Glycine N-acyltransferase-like protein 3 (GLYATL3)
- Target
- GLYATL3
- Molecular classification
- Enzyme, Acyltransferase
01
Overview
Glycine N-acyltransferase-like protein 3 (GLYATL3) is an enzyme that catalyzes the conjugation of long-chain fatty acyl-CoA thioesters and glycine to generate long-chain N-(fatty acyl)glycines, which serve as intermediates in the biosynthesis of fatty acid amides[1][3][5]. GLYATL3 is localized to the mitochondria and is predicted to play a role in lipid and fatty acid amide metabolism in mammalian systems[1][3][5]. Experimental knockdown of GLYATL3 leads to decreases in cellular levels of long-chain N-acylglycines and primary fatty acid amides, supporting its central function in this pathway[1]. The gene is not currently recognized as a direct drug target or receptor and no known drugs or specific safety concerns are reported in current biomedical databases[3]. GLYATL3 has also been linked as a gene of potential interest in cancer, specifically comedo carcinoma[3].
- Other names
- C6orf140bA28H17.2BA28H17.2Acyl-CoA:glycine-N-acyltransferase-like protein 3
02
Biological functions
Lipid metabolic processGlycine N-acyltransferase activityConjugation of long-chain fatty acyl-CoA thioesters with glycineFatty acid amide biosynthesis
03
Disease associations
Cancer (Comedo carcinoma)
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