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Target intelligence / Profile preview
Glycine Receptor Alpha 1 Subunit (GlyR alpha 1)
- Target
- GlyR alpha 1
- Molecular classification
- Ligand-gated ion channel, Receptor, Cys-loop receptor superfamily
01
Overview
The glycine receptor alpha 1 subunit is a key component of the glycine receptor (GlyR), a ligand-gated ion channel that mediates fast inhibitory neurotransmission in the central nervous system. Mutations in GLRA1 are associated with hyperekplexia, a rare neurological disorder characterized by exaggerated startle responses due to impaired inhibitory neurotransmission.
- Other names
- Alpha 1 glycine ReceptorGlyR alpha 1SPDSTHEGLRA1
02
Mechanism of action
Glycine binding increases chloride conductance, leading to membrane hyperpolarization and reduced neuronal excitability. Strychnine acts as an antagonist.
03
Biological functions
Inhibitory neurotransmissionChloride conductanceMotor controlSensory processingPain modulationBreathing regulation
04
Disease associations
HyperekplexiaEpilepsyTinnitus
05
Safety considerations
Impaired inhibitory neurotransmission can lead to neurological disorders like hyperekplexia.
06
Interacting drugs
Strychnine
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