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Target intelligence / Profile preview
Glycine receptor alpha 2 subunit (None)
- Target
- None
- Molecular classification
- Ligand-gated ion channel, Ion channel, Receptor
01
Overview
The glycine receptor alpha 2 subunit (GLRA2) is a protein that forms part of the glycine receptor, a neurotransmitter-gated ion channel that mediates fast inhibitory synaptic transmission in the central nervous system, particularly during early development. Activation increases chloride conductance leading to hyperpolarization—thus inhibiting neuronal firing. Mutations or dysfunctions involving GLRA genes can result in neurological disorders such as startle disease/hyperekplexia. Disruption specifically affecting GlyRα₂ impairs cortical interneuron migration—a process implicated by some studies as relevant to neurodevelopmental disorders including autism spectrum disorder.
- Other names
- GlyRα₂Neonatal glycine receptorStrychnine-binding subunitRNNEOGLY
02
Mechanism of action
Activation increases chloride conductance leading to hyperpolarization, thus inhibiting neuronal firing.
03
Biological functions
Chloride transmembrane transportIon transportNeurological system processNeuropeptide signaling pathwayRegulation of membrane potentialSynaptic transmission (glycinergic)Synaptic plasticity regulationGeneration of inhibitory postsynaptic currentsDown-regulation of neuronal excitability
04
Disease associations
Neurodevelopmental disordersHyperekplexia
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