Glycine-rich extracellular protein 1 (GREP1)

Glycine-rich extracellular protein 1 (GREP1) is a secreted, glycine-rich protein encoded by a previously non-canonical open reading frame (ORF G029442). It is highly expressed in human breast cancer and its knockout selectively reduces viability in breast cancer cell lines. GREP1 influences the abundance of the oncogenic cytokine GDF15 in the cancer cell secretome and is associated with reduced patient survival in breast cancer. Mass spectrometry indicates that GREP1 interacts with extracellular matrix proteins such as fibronectin and collagen. GREP1’s biological activity depends on protein translation (not just RNA presence), indicating it is a protein-coding gene rather than a non-coding RNA in cancer contexts. No documented drugs target GREP1 directly. It is considered a novel cancer vulnerability gene and possible therapeutic target[1].

Other names

GREP1Glycine-rich extracellular protein 1LINC00514G029442Long intergenic non-protein coding RNA 514LA16c-380H5.1LA16c-380H5.3