Glycine Transporter 1 (GlyT1)

Glycine transporter 1 (GlyT1), encoded by the SLC6A9 gene, is a sodium- and chloride-dependent membrane protein responsible for the reuptake of glycine from the synaptic cleft. It plays a crucial role in regulating glycine concentrations at inhibitory glycinergic synapses and modulating excitatory neurotransmission via NMDA receptors. Selective inhibitors that block GlyT1 increase extracellular synaptic glycine concentration—this potentiates NMDA receptor function. Mutations in SLC6A9 cause "glycine encephalopathy with normal serum glycine" (OMIM #617301), also known as GlyT1 encephalopathy.

Other names

SLC6A9GLYT1solute carrier family 6 member 9DKFZp547A1118

Inhibition of GlyT1 leading to increased synaptic glycine concentration and potentiation of NMDA receptor function.