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Glycine transporter type 1 (GlyT1)
- Target
- GlyT1
- Molecular classification
- Solute carrier family 6, Neurotransmitter:sodium symporter, Transporter
01
Overview
Glycine transporter type 1 (GlyT1) is a sodium- and chloride-dependent membrane protein responsible for the reuptake of glycine from the synaptic cleft, primarily in the central nervous system. GlyT1 plays a crucial role in regulating extracellular glycine concentrations, which directly impacts neurotransmission and NMDA receptor function. It is a therapeutic target for schizophrenia, cognitive disorders, and other neurological conditions.
02
Mechanism of action
Inhibition of GlyT1 increases extracellular synaptic glycine levels, potentiating NMDA receptor activity.
03
Biological functions
Glycine reuptakeRegulation of synaptic glycine concentrationModulation of NMDA receptor activityTermination of glycinergic signaling
04
Disease associations
SchizophreniaCognitive disordersEpilepsyMuscle tone defectsPain syndromesNeurodegenerative diseasesGlycine encephalopathy
05
Interacting drugs
Bitopertin
5 more in the full profile.
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