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Glycine transporter type 2 (GlyT2)
- Target
- GlyT2
- Molecular classification
- Neurotransmitter Sodium Symporter (NSS) Family, SLC6 Family, Transporter
01
Overview
Glycine transporter type 2 (GlyT2) is a sodium- and chloride-dependent glycine transporter belonging to the SLC6 family. Primarily expressed in neurons of the spinal cord, brainstem, and cerebellum, it plays a crucial role in glycinergic neurotransmission by regulating extracellular glycine concentrations at inhibitory synapses. GlyT2 mediates the reuptake of glycine into presynaptic terminals, enabling vesicular refilling and sustaining inhibitory signaling. It is a key target for modulating glycinergic neurotransmission.
- Other names
- SLC6A5
02
Mechanism of action
Competitive and non-competitive inhibition of glycine transport
03
Biological functions
Glycine reuptakeRegulation of glycinergic neurotransmissionVesicular refillingInhibitory neurotransmission
04
Disease associations
HyperekplexiaOther neurological disorders
05
Interacting drugs
ALX1393
1 more in the full profile.
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