Glyco-Immune Checkpoint

Glyco-immune checkpoints are immune-modulatory pathways involving interactions between glycans and glycan-binding proteins (lectins) on cell surfaces. They play a crucial role in regulating immune responses, particularly in cancer, where they can be co-opted by tumor cells to evade immune surveillance. Key components include glycans (especially sialylated glycans), Siglecs, and galectins. Targeting these checkpoints represents a novel approach to cancer immunotherapy by disrupting immunosuppressive signals and enhancing anti-tumor immunity.

Other names

Sialoglycan-Siglec axisGalectin-TIM3 pathway

Inhibition of glycan-lectin interactions to enhance anti-tumor immunity