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Target intelligence / Profile preview
Bile Salts
- Molecular classification
- Steroid derivative, Amphipathic molecule, Surfactant
01
Overview
Bile salts are the sodium (or potassium) salts of conjugated bile acids, which are steroid acids derived from cholesterol in the liver. They are a primary organic component of bile, a digestive fluid produced by the liver and stored in the gallbladder. Bile salts play essential roles in digestion, absorption of dietary fats and fat-soluble vitamins, elimination of waste products such as bilirubin and excess cholesterol, and modulation of gut microbiota.
- Other names
- Taurocholic acidGlycocholic acidTaurochenodeoxycholic acidGlycochenodeoxycholic acidDeoxycholateLithocholateUrsodeoxycholate
02
Mechanism of action
Emulsification of fats; cholesterol solubilization; FXR and GPBAR1/TGR5 receptor activation
03
Biological functions
Emulsification of dietary fatsDigestion of dietary fatsAbsorption of fat-soluble vitaminsCholesterol excretionRegulation of bile flowModulation of gut microbiota
04
Disease associations
Malabsorption syndromesGallstone formationCholestatic liver diseases
05
Safety considerations
Potential for diarrheaDrug interactionsExacerbation of certain liver conditions
06
Interacting drugs
Ursodeoxycholic acid
1 more in the full profile.
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