Target intelligence / Profile preview

Glycogen metabolism

Molecular classification
Enzyme, Metabolic pathway
01

Overview

Glycogen metabolism is a critical biological process that involves the synthesis (glycogenesis) and breakdown (glycogenolysis) of glycogen, a complex carbohydrate stored in the liver and muscles. It plays a central role in maintaining glucose homeostasis and energy balance. Glycogen metabolism is regulated by hormones such as insulin and glucagon and is an emerging target for therapeutic interventions in diseases like cancer and diabetes.

Other names
Glycogen synthesis and breakdownglycogenesisglycogenolysis
02

Mechanism of action

Inhibition of glycogen breakdown enzymes (e.g., glycogen phosphorylase); Activation of glycogen synthesis enzymes (e.g., glycogen synthase); Modulation of glycogen-metabolizing enzymes (e.g., PPP1R3C)

03

Biological functions

Energy storage and releaseRegulation of glucose homeostasisSignal transduction through hormonal control (e.g., insulin, glucagon)Cell metabolism and growth
04

Disease associations

CancerType 2 diabetesGlycogen storage diseasesInflammation
05

Safety considerations

Potential toxicity from depleting glycogen in certain tissuesHypoglycemia or hyperglycemia due to dysregulation of glucose metabolism
06

Interacting drugs

Metformin

3 more in the full profile.

07

Biomarkers

Glycogen levels in liver or muscle tissueglucose-6-phosphate levels

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