Glycogen metabolism pathway in lactic acid bacteria

The glycogen metabolism pathway in lactic acid bacteria involves the uptake of carbon sources, their conversion to glucose-1-phosphate, and subsequent synthesis of glycogen via a series of enzymes including phosphoglucomutase, ADP-glucose pyrophosphorylase (GlgC), glycogen synthase (GlgA), and glycogen branching enzyme (GlgB)[1][2][3][5]. Glycogen is stored intracellularly and acts as a survival resource during periods of nutrient deprivation, environmental stress, or in competitive host environments. Induction of glycogen synthesis, for instance by growing LAB on raffinose or trehalose, is associated with improved growth, bile resistance, and gastrointestinal tract persistence[1][2][3][6]. The overall concept is not a molecular "target" but rather a strategy to enhance the physiological robustness of probiotic LAB strains through manipulation of their central carbohydrate metabolism.

Other names

Glycogen metabolism in lactic acid bacteriaGlycogen synthesis in LABLAB glycogen induction

Not applicable for drugs; mechanism in context is induction of glycogen synthesis by providing appropriate carbon sources (e.g., raffinose, trehalose), which enhances LAB survival and stress tolerance