Target intelligence / Profile preview

Glycogen Phosphorylase (GP)

Target: GP
Molecular classification: Enzyme, Glycosyltransferase, Hexosyltransferase

Overview

Glycogen phosphorylase is a key enzyme in carbohydrate metabolism, catalyzing the rate-limiting step of glycogenolysis—the breakdown of glycogen into glucose-1-phosphate. It exists in multiple isoforms (muscle, liver, brain) with distinct regulatory properties. Regulation occurs through allosteric effectors and covalent modification (phosphorylation/dephosphorylation). It is a therapeutic target for metabolic diseases like type II diabetes.

Other names: PYGMPYGLPYGB

Mechanism of action

Inhibition of glycogen breakdown

Biological functions

GlycogenolysisGlucose homeostasisEnergy metabolismMobilizing stored glycogen

Disease associations

McArdle disease (type V GSD)Hers disease/GSDVIType II DiabetesCancer

Safety considerations

Hypoglycemia (with excessive inhibition)Potential for drug-induced glycogen storage diseases

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