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Glycogen Synthase 2 (GYS2)
- Target
- GYS2
- Molecular classification
- Enzyme, Transferase
01
Overview
Glycogen Synthase 2 (GYS2) is an enzyme that catalyzes the rate-limiting step in hepatic glycogen synthesis. It transfers glucose from UDP-glucose to a growing chain of glycogen, forming α-1,4-glycosidic bonds. GYS2 is essential for maintaining normal blood glucose levels by allowing rapid mobilization of stored liver glycogen. Mutations in GYS2 cause Glycogen Storage Disease Type 0 (GSD0), leading to fasting hypoglycemia.
- Other names
- Liver glycogen synthaseGYS2_HUMANGlycogen [starch] synthase, liver
02
Mechanism of action
Catalyzes the rate-limiting step in hepatic glycogen synthesis by transferring glucose from UDP-glucose to a growing chain of glycogen
03
Biological functions
Glycogen synthesisRegulation of blood glucose levels
04
Disease associations
Glycogen Storage Disease Type 0Hypoglycemia
05
Safety considerations
Hypoglycemia due to impaired glycogen synthesisLethargy during fasting
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