Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glycogen synthase kinase 3 beta (GSK-3β)
- Target
- GSK-3β
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
Glycogen synthase kinase-3 beta (GSK-3β) is a multifunctional serine/threonine protein kinase involved in numerous cellular processes, including cell cycle regulation, inflammation, proliferation, differentiation, apoptosis, and neuronal development. It regulates glycogen synthesis, energy metabolism, and cell signaling pathways such as the Wnt/β-catenin pathway. GSK-3β's activity is regulated by phosphorylation at Ser9 (inhibition) and Tyr216 (activation). Dysregulation of GSK-3β is implicated in various diseases, including bipolar disorder, diabetes, neurodegenerative diseases, cancer, and inflammatory disorders, making it a therapeutic target.
- Other names
- GSK3B
02
Mechanism of action
Phosphorylation of serine or threonine residues on target proteins, modulating activity. Small molecule inhibitors bind to the ATP binding site, preventing phosphorylation and downstream signaling.
03
Biological functions
Glycogen synthesis regulationEnergy metabolismCell signalingNeuronal cell developmentBody pattern formationCell cycle regulationInflammationProliferationDifferentiationApoptosis
04
Disease associations
Bipolar disorderDiabetesNeurodegenerative diseasesAlzheimer’s diseaseCancerInflammatory disorders
05
Safety considerations
Embryonic lethality in homozygous knockout micePotential for off-target effects due to broad substrate specificityComplex role in multiple signaling pathways requires careful consideration of potential unintended consequences when developing inhibitors.
06
Interacting drugs
Lithium
1 more in the full profile.
Beyond the preview
Go deeper on Glycogen synthase kinase 3 beta (GSK-3β).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glycogen synthase kinase 3 beta (GSK-3β).