Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glycohydrolase
- Molecular classification
- Enzyme, Hydrolase, Glycosidase
01
Overview
Glycohydrolases are a broad class of enzymes that catalyze the hydrolysis of glycosidic bonds in carbohydrates, glycoproteins, glycolipids, and related molecules. They play essential roles in various biological processes by breaking down complex sugars or sugar-containing structures. Key examples include Poly(ADP-ribose) Glycohydrolase (PARG), which regulates cellular processes such as DNA repair and cell death, and NAD+ Glycohydrolase, which participates in nicotinate/nicotinamide metabolism and calcium signaling. PARG is a therapeutic target for inflammation, ischemia-reperfusion injury, stroke, and cancer.
- Other names
- Poly(ADP-ribose) GlycohydrolasePARGNAD+ Glycohydrolase
02
Mechanism of action
Inhibition of glycohydrolase activity, specifically PARG, to modulate DNA damage response and cell death pathways.
03
Biological functions
Hydrolysis of glycosidic bondsCarbohydrate metabolismGlycoprotein metabolismGlycolipid metabolismDNA repairCell death signalingChromatin remodelingResponse to stressNicotinate/nicotinamide metabolismCalcium signaling
04
Disease associations
InflammationIschemia-reperfusion injuryStrokeCancerNeurodegenerative diseases
05
Safety considerations
Potential disruption of normal cellular metabolismOff-target effects on other glycosidases
Beyond the preview
Go deeper on Glycohydrolase.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glycohydrolase.