Target intelligence / Profile preview

Glycolate Oxidase

Molecular classification: Enzyme, Oxidase, FMN-dependent α-hydroxyacid oxidase

Overview

Glycolate oxidase (GO), also known as hydroxyacid oxidase 1 (HAO1), is a peroxisomal enzyme primarily responsible for the FMN-dependent oxidation of glycolate to glyoxylate and, subsequently, glyoxylate to oxalate. This enzyme plays a central role in glyoxylate metabolism and is implicated in the pathogenesis of primary hyperoxaluria type 1 (PH1) due to its involvement in oxalate production—a key factor in kidney stone formation. Targeting GO pharmacologically represents an emerging strategy for treating PHI by reducing hepatic oxalogenesis.

Other names: Hydroxyacid oxidase 1HAO1GOXGOX1HAOX1

Mechanism of action

Targeted inhibition of GO/HAO1 to reduce hepatic oxalogenesis.

Biological functions

Glycolate metabolismGlyoxylate metabolismOxalate production

Disease associations

Primary Hyperoxaluria Type 1 (PH1)Nephrolithiasis

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