Glycolysis-related enzyme

Glycolysis-related enzymes are a group of metabolic proteins that catalyze the reactions converting glucose into pyruvate within the cytosol, generating ATP and NADH for cellular energy and biosynthetic precursor production[8][10]. These include Hexokinase, Phosphofructokinase, Aldolase, Isomerase, Dehydrogenase, Kinase, Mutase, Enolase, and Pyruvate kinase[4][8][6]. Dysregulation, isoform variation, and overexpression of these enzymes are critical for the altered metabolism seen in cancer and other diseases, making them valuable therapeutic targets[1][9][7][5]. Because "Glycolysis-related enzymes" refers to a collective pathway and not a single target, the term is broad and not suitable for entry as a single canonical molecule. This entry is not specific to a single canonical protein, so detailed structured information for molecular databases should use one specific enzyme from the glycolytic pathway rather than the class as a whole[1][8][4].

Other names

Glycolytic enzymesenzymes of glycolysisglycolytic pathway enzymes

Inhibition of glycolytic enzyme activity (e.g., hexokinase inhibition reduces ATP production) Modulation of metabolic flux (shifting from glycolysis to oxidative phosphorylation) Interference with regulatory pathways (e.g., HIF-1α signaling and downstream glycolysis modulation)