Glycolytic and glycosylation pathway enzymes – general metabolic substrates

The term Glycolytic and glycosylation pathway enzymes – general metabolic substrates refers to a broad collection of proteins and metabolites involved in central carbon metabolism and protein modification. Glycolysis is the enzymatic process that converts glucose into pyruvate, generating ATP and NADH, and is frequently hijacked by cancer cells to support rapid growth through aerobic glycolysis [1]. Glycosylation involves the covalent attachment of glycans to proteins and lipids, a process essential for cellular signaling, immune evasion, and structural integrity [2]. Many enzymes within these pathways, such as Hexokinase, Phosphofructokinase, and O-GlcNAc transferase, are investigated as therapeutic targets to treat metabolic disorders and malignancies [3]. However, this designation is considered a pathway-level grouping rather than a single molecular target, presenting challenges for specific drug development and characterization [4]. Citations: [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849637/ [2] https://www.ncbi.nlm.nih.gov/books/NBK1908/ [3] https://pubmed.ncbi.nlm.nih.gov/30030518/ [4] https://www.nature.com/articles/nrd3505

Other names

Glycolysis enzymesGlycosylation enzymesMetabolic pathway enzymesCarbohydrate metabolism enzymes

Inhibition of enzymatic activity to disrupt glucose metabolism or protein post-translational modification.