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Glycoprotein 130 (gp130)
- Target
- gp130
- Molecular classification
- Type I transmembrane glycoprotein, Receptor
01
Overview
Glycoprotein 130 (gp130) is a type I transmembrane protein that serves as the common signal-transducing receptor subunit for the interleukin-6 (IL-6) family of cytokines. It plays a central role in mediating cellular responses to various cytokines, activating downstream pathways like JAK/STAT, PI3K/Akt, and MAPK/ERK. gp130-mediated signaling is essential for inflammatory responses, immune system regulation, hematopoiesis, and cardiac function. Disruption or dysregulation can contribute to diseases such as autoimmune disorders and cancers.
- Other names
- IL6STIL6R-betaCD130Interleukin‑6 signal transducerCDw130IL‑6ST
02
Mechanism of action
Modulation of downstream signaling pathways (JAK/STAT, PI3K/Akt, MAPK/ERK) through ligand binding and receptor dimerization/oligomerization.
03
Biological functions
Signal transductionImmune response modulationInflammationHematopoiesisEmbryonic developmentNeuronal survival/regenerationLiver regenerationAngiogenesisMetabolic regulation
04
Disease associations
Inflammatory responsesAutoimmune disordersCancersPulmonary arterial hypertension
05
Safety considerations
Aberrant inflammatory signalingCell proliferation control failures
06
Biomarkers
Elevated circulating IL-6 levels
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