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Target intelligence / Profile preview
Glycoprotein 91-phagocyte oxidase subunit (gp91^phox)
- Target
- gp91^phox
- Molecular classification
- Enzyme, NADPH oxidase subunit, Transmembrane protein
01
Overview
The gp91^phox subunit is a critical component of the phagocyte NADPH oxidase complex (cytochrome b_558). This enzyme complex is essential for the generation of reactive oxygen species (ROS), particularly superoxide, which plays a vital role in host defense mechanisms and cellular signaling. It mediates electron transfer from cytosolic NADPH to molecular oxygen across the membrane, resulting in superoxide production. Mutations in the gene encoding gp91^phox (CYBB) can cause chronic granulomatous disease.
- Other names
- NOX2CYBBCytochrome b_558
02
Mechanism of action
Inhibition of superoxide production
03
Biological functions
Electron transportSuperoxide generationHost defenseRespiratory burstROS signaling
04
Disease associations
Chronic granulomatous diseaseCardiovascular diseaseKidney disordersInflammationCancer
05
Safety considerations
Potential for immunosuppression if inhibited excessivelyOff-target effects due to homology with other NOX enzymes
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