Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glycoprotein A Repetitions Predominant (GARP)
- Target
- GARP
- Molecular classification
- Type I transmembrane glycoprotein, Receptor
01
Overview
GARP (Glycoprotein A Repetitions Predominant), also known as LRRC32, is a type I transmembrane glycoprotein that acts as a cell surface docking receptor for latent TGF-beta. It is highly expressed on activated FOXP3+ regulatory T cells (Tregs) and platelets and plays a crucial role in immune regulation and TGF-beta signaling. Targeting GARP has therapeutic potential for modulating Treg activity in autoimmune diseases and cancer immunotherapy.
- Other names
- LRRC32Leucine Rich Repeat Containing 32
02
Mechanism of action
Modulation of TGF-beta signaling through interaction with latent TGF-beta and regulation of Treg activity.
03
Biological functions
TGF-beta activationImmune regulationCell surface dockingTreg functionPlatelet function
04
Disease associations
Autoimmune diseasesCancerInflammation
05
Safety considerations
Potential for off-target effects on TGF-beta signalingPotential to disrupt immune homeostasisPotential for autoimmunity exacerbation or suppressionPotential to impact cancer progression or regression
06
Biomarkers
GARP expression on TregsGARP expression on platelets
Beyond the preview
Go deeper on Glycoprotein A Repetitions Predominant (GARP).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glycoprotein A Repetitions Predominant (GARP).