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Target intelligence / Profile preview
Glycoprotein-A Repetitions Predominant Protein (GARP)
- Target
- GARP
- Molecular classification
- Type I transmembrane protein, Receptor
01
Overview
Glycoprotein-A repetitions predominant protein (GARP), also known as leucine-rich repeats containing 32 (LRRC32), is a type I transmembrane protein that functions as a cell surface docking receptor for latent transforming growth factor beta (LTGF-β), modulating its activation and bioavailability. It is primarily expressed on activated regulatory T cells (Tregs) and plays a key role in immune regulation and tumor microenvironment modulation.
- Other names
- LRRC32Leucine-rich repeat containing 32DI1S863E
02
Mechanism of action
Modulation of TGF-β activation and bioavailability
03
Biological functions
Latent TGF-β bindingTGF-β activationImmune suppressionTissue homeostasisCell-surface docking receptor
04
Disease associations
CancerImmune disordersDevelopmental disorders
05
Safety considerations
Potential for off-target effects on TGF-β signaling in non-immune cellsRisk of disrupting immune homeostasisTumor-specific expression and effects need to be considered
06
Biomarkers
GARP expression on TregsSoluble GARP levels
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