Target intelligence / Profile preview

Glycoprotein B (gB)

Target: gB
Molecular classification: Viral Fusion Protein, Glycoprotein, Type I transmembrane protein

Overview

Glycoprotein B (gB) is a highly conserved, essential viral fusion protein found in all herpesviruses. It mediates the fusion of the viral envelope with host cell membranes, enabling viral entry into target cells. gB also plays a role in virion assembly and egress. As a surface protein, gB is a target for neutralizing antibodies. Drugs and vaccines targeting gB are under development.

Mechanism of action

Conformational change exposes hydrophobic loops, which insert into the host cell membrane and drive membrane fusion.

Biological functions

Viral entryMembrane fusionVirion assemblyVirion egress

Disease associations

Infection

Safety considerations

Potential for off-target effects if drugs targeting gB also affect similar host cell proteins.Development of drug resistance.

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Drug pipeline

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