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Target intelligence / Profile preview
Varicella-zoster Virus Antigen (VZV Antigen)
- Target
- VZV Antigen
- Molecular classification
- Viral protein, Glycoprotein, Envelope glycoprotein
01
Overview
Varicella-zoster virus antigens—primarily envelope glycoproteins such as gE—are essential structural proteins involved in viral infectivity, pathogenesis, immune evasion/modulation, diagnosis via serology, and serve as key targets/components for effective vaccination strategies against chickenpox and shingles.
- Other names
- VZV GlycoproteinGlycoprotein E (gE)Glycoprotein B (gB)Glycoprotein H (gH)Glycoprotein L (gL)
02
Mechanism of action
Antibody-mediated neutralization of viral entry and spread
03
Biological functions
Viral entry/fusionCell-to-cell spreadImmune recognitionViral replication
04
Disease associations
Chickenpox (Varicella)Shingles (Herpes Zoster)Infection
05
Safety considerations
Potential for vaccine-related adverse reactions (e.g., injection site pain, fever)Rare cases of herpes zoster following vaccination
06
Interacting drugs
Vaccines (e.g., Shingrix®)
07
Biomarkers
Anti-VZV IgG antibodiesgE-specific antibodies
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