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Target intelligence / Profile preview
Glycoprotein NMB (GPNMB)
- Target
- GPNMB
- Molecular classification
- Type I transmembrane glycoprotein
01
Overview
Glycoprotein NMB (GPNMB) is a type I transmembrane glycoprotein involved in bone biology, immune regulation, and tumor progression. It is overexpressed in several aggressive tumors, making it a prognostic marker and therapeutic target. It promotes tumor formation and malignancy traits such as migration, dormancy, and tumorigenicity.
- Other names
- OsteoactivinOADC-HILHGFIN
02
Mechanism of action
Antibody-drug conjugate; cytotoxic activity
03
Biological functions
Bone formationBone remodelingImmune modulationTumor progressionChondrogenesisOsteogenesisCell migrationCell dormancyCell proliferation
04
Disease associations
CancerPrimary localized cutaneous amyloidosis type 3Lichen amyloidosis
05
Safety considerations
Unknown safety concerns, clinical trials ongoing
06
Interacting drugs
Glembatumumab vedotin
07
Biomarkers
GPNMB overexpression in tumor tissue
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