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Target intelligence / Profile preview
Glycoprotein non-metastatic melanoma protein B (GPNMB)
- Target
- GPNMB
- Molecular classification
- Type I transmembrane glycoprotein
01
Overview
Glycoprotein NMB (GPNMB) is a type I transmembrane glycoprotein involved in cell adhesion, migration, differentiation, and bone remodeling. It is overexpressed in several cancers and plays a role in immune modulation and inflammation. As a therapeutic target, GPNMB is being explored for cancer immunotherapy using antibody-drug conjugates. It is also implicated in cardiovascular repair following myocardial infarction, suggesting potential therapeutic applications in regenerative medicine.
- Other names
- OsteoactivinOADC-HILHGFINNMB
02
Mechanism of action
Glembatumumab vedotin/CDX-011: Antibody-drug conjugate that binds GPNMB, internalizes into the cell, and releases a cytotoxic payload (vedotin) to kill cancer cells.
03
Biological functions
Cell adhesionCell migrationCell differentiationBone formationBone remodelingImmune modulationInflammationCardiac repairAngiogenesis
04
Disease associations
CancerOsteoporosisOsteopeniaAutoimmune disordersInflammatory disordersCardiovascular disease
05
Safety considerations
Potential for off-target effects due to GPNMB expression in normal tissues (e.g., melanocytes, osteoclasts)Drug resistance in cancer cells due to downregulation of GPNMB expressionImmunogenicity of antibody-based therapies
06
Interacting drugs
Glembatumumab vedotin
1 more in the full profile.
07
Biomarkers
GPNMB expression in tumorsGPNMB levels in serum/plasma (potential biomarker for cardiovascular disease)
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