Glycoprotein VI (collagen receptor) (GPVI)

Glycoprotein VI (GPVI) is a platelet-specific membrane receptor and major component of the platelet response to collagen exposure during vascular injury. GPVI is a member of the immunoglobulin superfamily and associates with the Fc receptor gamma chain, which carries an ITAM motif essential for downstream tyrosine kinase signaling[4][5]. Collagen binding to dimeric GPVI activates this pathway, leading to platelet activation, aggregation, and thrombus formation[2][5][7]. Integrin α2β1 plays a complementary role in mediating platelet adhesion but not activation. Variations in GPVI expression can influence thrombosis risk and bleeding disorders, making it a central therapeutic and diagnostic target in platelet biology[1][5][7].

Other names

Platelet collagen receptorGlycoprotein VIGPVIIntegrin α2β1 (secondary/adhesive collagen receptor)Collagen receptor of plateletsCD36 and the GPIIb/IIIa do not serve as signaling collagen receptors in platelets

Drugs/inhibitors block GPVI-collagen interaction to prevent platelet activation - Inhibition of ITAM phosphorylation and downstream tyrosine kinase signaling - Preventing GPVI dimerization or signalling blocks thrombus formation