Glycoprotein VI receptor (GPVI)

Glycoprotein VI receptor (GPVI) is a platelet membrane glycoprotein that serves as the primary receptor for collagen in platelets. It plays a central role in platelet activation, aggregation, and thrombus formation following vascular injury. Upon binding to exposed collagen at sites of vascular damage, GPVI triggers a signaling cascade that leads to platelet adhesion, activation, and aggregation, forming the initial hemostatic plug. Deficiency or inhibition of GPVI impairs collagen-induced platelet activation, which can manifest clinically as a mild bleeding tendency but is also a promising strategy for antithrombotic therapy, as it may reduce the risk of arterial thrombosis with potentially less risk of severe bleeding compared to current antiplatelet drugs[1][2][3][5].

Other names

Platelet glycoprotein VIcollagen receptor GPVI

Inhibition of GPVI blocks platelet activation and reduces thrombus formation by preventing GPVI-collagen binding, thereby inhibiting downstream platelet signaling[3].