Glycosylated lysosomal membrane protein (GLMP)

Glycosylated lysosomal membrane protein (GLMP) is a highly glycosylated, single-pass transmembrane protein found on the lysosomal membrane where it serves as an essential accessory subunit for the lysosomal dipeptide transporter MFSD1. GLMP protects MFSD1 from lysosomal proteolysis and is required for its proper localization to the lysosome. The MFSD1-GLMP complex functions as a general uniporter for cationic, neutral, and anionic dipeptides, establishing an alternative export pathway for proteolysis products in lysosomes. Deficiency of GLMP (or MFSD1) leads to severe organ dysfunction, highlighting its importance in cellular degradation and metabolite recycling. Although closely related to other lysosomal membrane proteins (such as LAMP family proteins), GLMP is a distinct protein and critical for lysosomal transporter function.

Other names

C1orf85PSEC0030UNQ2553/PRO6182MGC31963NCU-G1Lysosomal protein NCU-G1Kidney lysosomal membrane proteinGlycosylated lysosomal membrane proteinlnc-UCID

No drugs targeting GLMP explicitly; mechanisms for potential targeting would likely involve modulation of MFSD1-GLMP transporter function or lysosomal stability.