Target intelligence / Profile preview

Glycosylphosphatidylinositol anchor biosynthesis protein (GWT1)

Target: GWT1
Molecular classification: Enzyme, Acetyltransferase, Acyltransferase, Membrane protein

Overview

Gwt1 (GPI-anchored wall transfer protein 1) is an integral membrane protein involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors, which are essential for attaching certain proteins to the cell surface in eukaryotes. It functions as an acetyltransferase or acyltransferase, specifically catalyzing the acylation of the inositol ring of phosphatidylinositol during GPI-anchor biosynthesis. It is a validated antifungal target.

Other names: GPI-anchored wall transfer protein 1

Mechanism of action

Inhibition of GWT1-mediated inositol acylation

Biological functions

Glycosylphosphatidylinositol (GPI) anchor biosynthesisProtein modificationLipid modification

Disease associations

Infection

Interacting drugs

Manogepix

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