Glycosylphosphatidylinositol-anchored molecule-like protein (GML)

Glycosylphosphatidylinositol-anchored molecule-like protein (GML) is a low molecular weight cell surface protein that belongs to the Ly-6/uPAR superfamily, characterized by the presence of a single LU domain with conserved cysteine residues. GML is tethered to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Ly-6/uPAR family proteins, including GML, are typically expressed on lymphocytes, certain tumor cells, and during various stages of hematopoiesis. These proteins are implicated in immune system function and tumorigenesis, making them relevant as diagnostic markers and potential therapeutic targets, especially in cancer immunotherapy[1][3]. The precise physiological role of GML remains an area of investigation, but related proteins in this superfamily mediate functions such as T-cell activation, cell signaling, and possibly the regulation of cell fate[1][3].

Other names

Ly6DLLY6DLglycosyl-phosphatidylinositol-anchored molecule-like proteinGPI-anchored molecule-like proteinGML