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Target intelligence / Profile preview
Glycosylphosphatidylinositol-Anchored Wall Transfer Protein 1 (GWT1)
- Target
- GWT1
- Molecular classification
- Wall Transfer Protein, GPI-anchored protein
01
Overview
Glycosylphosphatidylinositol-anchored wall transfer protein 1 (GWT1) is a eukaryotic protein modified with a glycosylphosphatidylinositol (GPI) anchor, tethering it to the plasma membrane. In fungi, it localizes mannoproteins within the cell wall. GPI-anchored proteins have diverse roles including structural support, signaling, and adhesion. GWT1 is a target for antifungal compounds like 1-[4-butylbenzyl]isoquinoline, which disrupt fungal cell wall assembly.
02
Mechanism of action
Interference with GWT1 function, disrupting fungal cell wall assembly and integrity.
03
Biological functions
Cell wall assemblyMannoprotein localizationCellulose microfibril organizationSignal transduction
04
Disease associations
Infection
05
Interacting drugs
1-[4-butylbenzyl]isoquinoline
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